Powerful single-cell transcriptome analysis in a simple UI
Explore hundreds of curated single-cell transcriptome datasets, along with your own data, through interactive visualizations and analytics. The software also supports multimodal omics, e.g. CITE-seq, TCR-seq, spatial transcriptomics.
Interactively explore the world's largest single-cell expression database
Access and query insights from a single cell database of millions of cells, fully annotated with cell type labels and experimental metadata.
Learn more about the curated database
Transform raw in-house data into insights
Not just creating a gateway to published works, BBrowser is an end-to-end solution for YOUR own single-cell data. Import your fastq files, count matrices, Seurat or Scanpy objects and reveal the biological stories inside them.
All-in-one preprocessing and downstream analytics. Simple to run.
Get a rich package of visualizations and analyses in an intuitive interface, making insight mining from any curated or in-house single-cell dataset become such a breeze.
Free download
Query gene expression
Find differentially expressed genes between two groups
Find marker genes and enriched processes (source: Reactome)
Sub-cluster any cell populations
Study cell fate decisions with single cell trajectory analysis
Search similar cell populations in the entire database
Harness the synergy of multimodal single-cell omics
Try now
Single-cell CRISPR screening data analysis
Import single-cell CRISPR screening or Perturb-seq data. Query guide RNA sequences
CITE-seq data analysis
Unravel protein expression together with gene activity
Combine TCR information with gene expression
Study clonotype expansion in combination with single-cell RNA-seq data
Compatibility with spatial transcriptomics data
BBrowser single-cell analytics and visualizations are also compatible with spatial transcriptomics data from 10X Genomics Visium and NanoString DSP technologies, accommodating effortless exploration of gene activities in the tissue context.
View more spatial capabilitiesBioturing BBrowser is a very helpful software for researchers to explore and discover the hidden gems in the scRNA-seq data. It is easy to install and learn, and does not require coding background. It is also user friendly and full of customizations for both exploratory and publication purposes. One of the best parts of this software is that it can easily load and process a wide range of data types, such as scRNA-seq, scATAC-seq, and spatial transcriptomics. It also provides some of the best tools to filter, cluster and analyze the data.
Li Cai - PhD Student, MD Anderson Cancer Center
Bioturing scRNA-seq software greatly accelerates and enables our research, through easy to use intuitive analytics, visualization and extensive database of curated and pre-processed experiments
Eugene Bolotin - Senior Bioinformatics Scientist, Kite Pharma
BBrowser allows biologists to handle scRNA-seq data without programming knowledge. Intuitive operation. Functions are updated. Public data can be imported. It is very helpful.
Researcher (Pharmacology), Chugai Pharmaceutical
The Bioturing Browser with single cell add-on provides one of the simplest interfaces for quickly moving from raw data to cluster analyses with minimal experience. The built-in HeraT alignment processes are remarkably quick and less computationally intensive than other scRNA-seq offerings.
Chris Ahuja - University of Toronto.
Bioturing Browser is an intuitive and powerful software for exploration and visualization of scRNA-Seq data. Its fast and easy access to the vast amounts of curated datasets is very helpful for our drug discovery research.
Niv Sabath - Senior Scientist, Compugen
The BioTuring Browser is a game changer in the Immune Oncology field to speed up single cell data sharing among biologists, immunologists and bioinformaticians. Empowering collaboration in annotating cells, discovering unknown cell populations, cell states or cell interactions is crucial to draw the best picture ever of the highly heterogenous tumor microenvironment. Users have access to a growing public as well as their private knowledge base, which makes the BioTuring platform a swiss-army-knife for better understanding cells at the single cell level.
Molecular Oncology and Immunology Lab, IFOM
I came across BBrowser while going through the Bioturing website and have been very impressed by the ease of use, capacity and capability of this unique platform. Within minutes from starting to use this tool, I was able to download single-cell sequencing datasets with metadata, obtain visualizations and biostatistical analyses including correlation and hierarchical clustering, analyse data by age, sex and pathology and carry differential gene expression analyses for my genes of interest. Overall, an amazing tool to have for every researcher engaged in scRNA approaches. Kudos to the developers for bringing this amazing platform to academics engaged in single-cell research. Looking forward to the addition of more studies/workflows and features to this already exciting software!
Anand Hardikar, Western Sydney University, Sydney Australia
BBrowser is an amazing software for analysis of single cell RNA sequencing data. It provides seamless integration with the analyzed data from R (not that it's required), and allows you to do differential expression, gene set enrichment, and pseudotime trajectory analysis very quickly and efficiently. I would also have to say that the "identify cell cluster" function, which compares your cell clusters to all the cell annotations available on the BBrowser database, has been amazing for me in identifying cell types that I didn't even know were present within my dataset. I highly recommend that everyone try out this software - both novice and veteran computational biologists alike will enjoy using it! The user interface is very intuitive, and the learning curve is not steep at all. Plus, Bioturing customer support is always available to help with any issues you may encounter during the course of your analysis.
Sanjid Shahriar, Agalliu Lab, Department of Neurology, Columbia University Irving Medical Center
BBrowser is an outstanding software to analyze single-cell datasets intuitively without programming knowledge. It powerfully supports not only identifying the known cluster or marker genes, but also performing further downstream analysis such as trajectory or gene set enrichment analysis.
Department of Preventive Medicine, The University of Tokyo
Bioturing BBrowser is a very helpful software for researchers to explore and discover the hidden gems in the scRNA-seq data. It is easy to install and learn, and does not require coding background. It is also user friendly and full of customizations for both exploratory and publication purposes. One of the best parts of this software is that it can easily load and process a wide range of data types, such as scRNA-seq, scATAC-seq, and spatial transcriptomics. It also provides some of the best tools to filter, cluster and analyze the data.
Li Cai - PhD Student, MD Anderson Cancer Center
Bioturing scRNA-seq software greatly accelerates and enables our research, through easy to use intuitive analytics, visualization and extensive database of curated and pre-processed experiments
Eugene Bolotin - Senior Bioinformatics Scientist, Kite Pharma
Publications
Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling
Nature Communications 13.1 (2022): 1-17
Orliaguet, L., et al. - August 30, 2022Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis
Nat Commun 13, 4170 (2022).
Caporarello, Nunzia, et al.. - July 25, 2022.Epicutaneous allergen immunotherapy induces a profound and selective modulation in skin dendritic cell subsets
Journal of Allergy and Clinical Immunology (2022).
Laoubi, Léo, et al. - Online June 30, 2022.Interleukin-signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma
Cancer Discov candisc.
Aghayev, Turan, et al. - June 3, 2022.Understanding of Retinal Degeneration Through the Lens of High Throughput Gene Expression
The Australian National University (Australia) ProQuest Dissertations Publishing, 2022. 29070861.
Cioanca, Adrian V. - May, 2022.The Role of FOXDin Clear Cell Renal Cell Carcinoma .
Electronic Theses and Dissertations. 3567.
Bond, Kyle H. - May, 2022.Interferon regulatory factor (IRF1) controls the metabolic programmes of low-grade pancreatic cancer cells
Gut (2022)
Alfarano, Gabriele, et al. - Published Online First: May 13, 2022.Refining colorectal cancer classification and clinical stratification through a single-cell atlas.
Genome biology 23.1 (2022)
Khaliq, Ateeq M., et al. - May 11, 2022Transcriptomic profiles of neoantigen-reactive T cells in human gastrointestinal cancers
Cancer Cell 40.4
Zheng, Chunhong, et al. - April 11, 2022Intratumoral electroporation of plasmid encoded IL-and membrane-anchored anti-CD3 increases systemic tumor immunity
Molecular Cancer Research.
Han, Mia, et al.. - March 10 2022Single-cell immune profiling reveals novel thymus-seeding populations, T cell commitment, and multi-lineage development in the human thymus
bioRxiv. 2022.
Cordes, Martijn, et al. - Preprint: February 19, 2022.Transcriptional analysis of lung fibroblasts identifies PIMsignaling as a driver of aging-associated persistent fibrosis
JCI Insight. 2022.
Pham, Tho X., et al. - Published February 15, 2022Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia
American Journal of Physiology-Lung Cellular and Molecular Physiology.
Na, Elim, et al. - Published February 09, 2022Soxinduces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications
Signal Transduction and Targeted Therapy, 7(1), 1-12.
Lopez-Bertoni, Hernando, et al. - February 09, 2022The Role of the Extracellular Matrix and Tumor-Infiltrating Immune Cells in the Prognostication of High-Grade Serous Ovarian Cancer
Cancers, 14(2), 404.
Belotti, Yuri, Elaine Hsuen Lim, and Chwee Teck Lim - January 14, 2022Heme-stress activated NRFskews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia
Cell Death & Differentiation, 1-16.
Vallelian, Florence, et al. - January 14, 2022Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes
Genes,12(12), 2015.
Gudiseva, Harini V., et al. - December 18, 2021Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes
Frontiers in oncology, 11, 734959-734959.
Pullikuth, Ashok K., et al. - December 08, 2021Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes
Arthritis research & therapy, 23(1), 1-10.
Ghodke-Puranik, Yogita, et al. - November 30, 2021Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer
Journal for immunotherapy of cancer, 9(11).
Sprooten, Jenny, et al. - November 18, 2021Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis.
PLoS pathogens 17.11.
Nguyen, Hang Thi Thu, et al. - November 11, 2021Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity
Immunity, 54(10), 2354-2371.
Sharma, Madhav D., et al - October 12, 2021PD-stimulated T cell subsets are transcriptionally and functionally distinct
Iscience, 24(9), 103020.
Lerrer, Shalom, et al. - September 24, 2021Functional microRNA targetome undergoes degeneration-induced shift in the retinal
Molecular neurodegeneration, 16(1), 1-21.
Chu-Tan, Joshua A., et al - August 19, 2021Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cell
Antimicrobial agents and chemotherapy, 65(9), e00602-21.
Li, Ruidong, et al. - August 17, 2021DNA Methylome Alterations are Associated with Airway Macrophage Differentiation and Phenotype During Lung Fibrosis
American Journal of Respiratory and Critical Care Medicine ja (2021).
McErlean, Peter, et al. - July 19, 2021High-resolution transcriptional landscape of xeno-free human induced pluripotent stem cell-derived cerebellar organoids
Scientific reports, 11(1), 1-17.
Nayler, Samuel, et al. - June 21, 2021Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders
Science, 373(6553), eabf9277.
Brioschi, Simone, et al. - June 03, 2021Early memory differentiation and cell death resistance in T cells predicts melanoma response to sequential anti-CTLAand anti-PD1 immunotherapy
Genes & Immunity, 22(2), 108-119.
Vanmeerbeek, Isaure, et al. - June 02, 2021Single-cell Transcriptomics Uncover a Novel Role of Myeloid Cells and T-lymphocytes in the Fibrotic Microenvironment in Peyronie’s Disease
European Urology Focus.
Milenkovic, Uros, et al. - May 04, 2021Space-occupying brain lesions, trauma-related tau astrogliopathy, and ARTAG: a report of two cases and a literature review
Acta Neuropathologica Communications, 9(1), 1-15.
Bachstetter et al. - March 23, 2021Galectin-interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
Nature communications, 12(1), 1-17.
Yang, Riyao, et al. - February 05, 2021Mediators of SARS-CoV-entry are preferentially enriched in cardiomyocytes
Hereditas,158(1), 1-8.
Jing Yang, Tan Chen & Yafeng Zhou - January 04, 2021Identification of a subset of immunosuppressive PX1-negative neutrophils in pancreatic cancer liver metastasis
Nature communications, 12(1), 1-17.
Wang, Xu , et al. - January 08, 2021In silico immune infiltration profiling combined with functional enrichment analysis reveals a potential role for naïve B cells as a trigger for severe immune responses in the lungs of COVID-patients
PLoS ONE 15(12): e0242900.
Wu, Yi-Ying, et al. - December 02, 2020Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis
Developmental Cell 55, 1–15.
Milan, Marta, et al. - November 23, 2020The Chemical Biology of Long Noncoding RNAs
Springer Nature Switzerland AG, RNA Technologies 11, p.122.
Stefan Jurga, Jan Barciszewski (Editors) - 2020Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes
bioRxiv.
Paulsen, Bruna, et al. - Preprint: November 12, 2020The balance of stromal BMP signaling mediated by GREMand ISLR drives colorectal carcinogenesis
Gastroenterology, 160(4), 1224-1239.
Kobayashi, Hiroki, et al. - November 13, 2020Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes
The Journal of clinical investigation, 130(10), 5576-5590.
Pfefferlé, Marc, et al. - September 14, 2020Comparison of visualization tools for single-cell RNAseq data
NAR genomics and bioinformatics, 2(3), lqaa052.
Cakir, Batuhan, et al. - July 29, 2020