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Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions
Lin, Wei and Noel, Pawan and Borazanci, Erkut H and Lee, Jeeyun and Amini, Albert and Han, In Woong and Heo, Jin Seok and Jameson, Gayle S and Fraser, Cory and Steinbach, Margaux and others
Solid tumors such as pancreatic ductal adenocarcinoma (PDAC) comprise not just tumor cells but also a microenvironment with which the tumor cells constantly interact. Detailed characterization of the cellular composition of the tumor microenvironment is critical to the understanding of the disease and treatment of the patient. Single-cell transcriptomics has been used to study the cellular composition of different solid tumor types including PDAC. However, almost all of those studies used primary tumor tissues.