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A Single Cell Transcriptomic Atlas Characterizes Aging Tissues in the Mouse
Pisco, Angela Oliveira, Schaum, Nicholas, McGeever, Aaron, Karkanias, Jim, Neff, Norma F, Darmanis, Spyros, Wyss-Coray, Tony, Quake, Stephen R
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death 1. Despite rapid advances over recent years 2, many of the molecular and cellular processes which underlie progressive loss of healthy physiology are poorly understood. To gain a better insight into these processes we have created a single cell transcriptomic atlas across the life span of Mus musculus which includes data from 18 tissues and organs. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence 3, changes in the activity of metabolic pathways 4, depletion of stem-cell populations 5, genomic instability 6 and the role of inflammation as well as other changes in the organism’s immune system2. This Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.